Searchable abstracts of presentations at key conferences on calcified tissues

ba0001pp239 | Cell biology: osteocytes | ECTS2013

Glycosaminoglycans and their sulfate derivates differentially regulate the osteocytic phenotype of murine and rat osteocyte-like cell lines

Tsourdi Elena , Salbach-Hirsch Juliane , Rauner Martina , Richter Claudia , Rachner Tilman , Hofbauer Lorenz

Introduction: Collagen and glycosaminoglycans (GAGs) such as hyaluronan (HA) and chondroitin sulfate (CS) are basic elements of bone structure and collagen-GAG composites are currently developed for a wide range of applications. Here, we report on the molecular and cellular effects of GAGs and their sulfated derivatives on osteocytes, which are fundamental orchestrators of bone remodeling.Materials and methods: The effects of native and sulfate-modified ...